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Diplomate
Spain
48160 Derio, Bizkaia, Spain

Slow infections, epidemiology, vaccines

After graduating in Veterinary Medicine at the University of Zaragoza in 1979, I developed a short period of clinical practice in Aragon. Then, in 1982, I joined the Servicio de Investigación y Mejora Agraria del Departamento de Agricultura (SIMA) of the Basque Government helping to build up the new structure of Agricultural research in the Basque Country, as well as a veterinary laboratory diagnostic service. During those years I participated in the first descirptions of several diseases not yet formally reported in Spain (bovine paratuberculosis, besnoitiosis, heredaitry parakeratosis in calves, Oslerus rostratus in cats, etc.). The need to face bovine paratuberculosis marked my introduction to mycobacterial diseases that has been my main line of work throughout my proffesional career. In general, the innovative and collaborative atmosphere in SIMA and then NEIKER, allowed my implication in other problems, like small ruminant lentivirus, that as a model of slow infection has underlined a common perspective with mycobacteriosis and prionopathies in my scientific works.

Apart from short stages in European universities and research centers like the Tierärztliche Hochschule Hannover in 1979, my more extensive international experience took place at the universities of Nebraska (1991-1992) and Texas A&M (1994-1995) working on mycobacterial and virological classical and molecular techniques, as well as on experimental infections in ruminants.

From 1998 until 2015 I have been Head of the Department of Animal Health of NEIKER. Our group was the only that succeeded in the isolation of the H5N1 strain of avian influenza in the Iberian peninsula. Later on, we also showed the first case of long distance aerial transmission over land of C. imicola that caused the blue tongue outbreak in the North of Spain. I have also inspired and directed the epidemiological and clinical works that led to the paradigm shift between mainly vertical to mainly horizontal transmission of maedi-visna infection.

My main scientific contributions are focused on mycobacteriosis where we succeeded for the first time in the isolation of some sheep strains of M.a. subsp. paratuberculosis. I also have contributed to demonstrate the eficiency of paratuberculosis vaccination, using sheep for developing the first simulation on epidemiologic and economic performance. Later I set up and directed the only bovine field clinical trial in Europe that has allowed the registration of a commercial vaccine in France and Australia by a Spanish company. Additionally, I have proposed pathogenetic trans-specific models of inflammattory bowel disease, including studies in the human species. In the field of tuberculosis, I proposed the use of inactivated vaccines against the current dogma, that supported other groups are showing an efficacy even higher than BCG in some animal models.

My main interest at this moment is to demonstrate the existence of a common innate mechanism for slow inflammatory diseases in animals and humans and its control by active immunotherapy.

After four years as Managing Director of the Asturias Agri-Food Research and Development Regional Service, I am back to Neiker.

Other

Member of the Editors Panel for Medicina Veterinaria (Veterinary Medicine) since 1984 until its closing in 1999.

Associate Editor on Epidemiology (Animal Health and Welfare) for the Spanish Journal of Agricultural Research from February 2011 until 2015.

Editor on Animal Health and Welfare for the Spanish Journal of Agricultural Research since 2015.

Editor for Heliyon by Elsevier since November 2016

Member of the Editorial Board of “Veterinaria Mexico OA” since June 2013.

President of the International Association for Paratuberculosis (IAP) from 2 november 2007 to june 2018.

President of the Asociación Española de Veterinarios Especialistas en Diagnóstico de Laboratorio (AVEDILA – Spanish Association of Veterinary Laboratory Diagnosticians) since 18 june 2009 to November 2017.

Member of the Academia de Ciencias Médicas de Bilbao (Academy of Medical Sciences of Bilbao) and President of the Veterinary Section since november 2009.

I am ranked 500 out of the world 54881 most cited scientists in Veterinary Sciences according to Baas, Jeroen; Boyack, Kevin; Ioannidis, John P.A. (2021), “August 2021 data-update for "Updated science-wide author databases of standardized citation indicators"”, Mendeley Data, V3, doi: 10.17632/btchxktzyw.3

Some relevant publications (2019 Google Scholar H index: 48)
Detection of Small Ruminant Lentivirus in environmental samples of air and water. Villoria M. Leginagoikoa I, Lujan L, Perez M, Salazar E, Berriatua E, Juste RA, Minguijon E. Small Ruminant Research 110:155–160. 2013. http://dx.doi.org/10.1016/j.smallrumres.2012.11.025
Control of brucellosis and of respiratory Small Ruminant Lentivirus infection in small ruminants in the Basque country, Spain. Juste RA, Leginagoikoa I, Villoria M, Minguijon E, Elguezabal N, Boix C, Arrazola I, Perez K, Gonzalez L. Small Ruminant Research 110 (2013) 115– 119. http://dx.doi.org/10.1016/j.smallrumres.2012.11.017.
Single-nucleotide polymorphisms in the bovine CD209 candidate gene for susceptibility to infection by Mycobacterium avium subsp. Paratuberculosis. Ruiz-Larrañaga O, Iriondo M, Manzano C, Agirre M, Garrido JM, Juste JA, Estonba A. Anim Genet. 43(5):646-7. doi: 10.1111/j.1365-2052.2011.02316.x. 2012.
Association between Mycobacterium avium subsp paratuberculosis DNA in blood and cellular and humoral immune response in inflammatory bowel disease patients and controls Juste, Ramon A.; Elguezabal, Natalia; Pavon, Andres; Garrido, Joseba M.; Geijo, Marivi; Sevilla, Iker; Cabriada, Jose L.; Tejada, Angel; Garcia-Campos, Francisco; Casado, Roberto; Ochotorena, Itziar; Izeta, Ander INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES 2009 13 247 254 10.1016/j.ijid.2008.06.034
Dynamics of cell-associated viremia and antibody response during the early phase of lentivirus infection in sheep Juste, RA; Kwang, J; de la Concha-Bermejillo, A AMERICAN JOURNAL OF VETERINARY RESEARCH 1998 59 563 568
A Candidate SNP in the Bovine SP110 Gene is not Associated with Susceptibility to Tuberculosis in Cattle. Ruiz-Larrañaga O, Manzano C, Iriondo M, Garrido JM, Aguirre M, Vazquez P, Juste RA, Estonba A. Int J Anim Vet Advan 3(6)407-408. 2011.
SNPs in APOBEC3 cytosine deaminases and their association with Visna/Maedi disease progression. Esparza-Baquer A, Larruskain A, Minguijon E, Juste RA,Benavides J, Perez V, Jugo B. Vet Immunol Immunopathol. 11/2014. DOI: 10.1016/j.vetimm.2014.11.007. 2014
SNPs in candidate genes MX dynamin-like GTPase and chemokine (C-C motif) receptor-5 are associated with ovine pulmonary adenocarcinoma progression in Latxa sheep. Larruskain A, Esparza-Baquer A, Minguijon E, Juste RA, Jugo BM ANIMAL GENETICS, 46: 666-675. DOI: 10.1111/age.12351. 2015
Presence of cytoecetes-phagocytophila in an atypical disease of cattle in Spain. JUSTE, RA; SCOTT, GR; PAXTON, EA; GELABERT, JL; JIMENEZ, S VETERINARY RECORD 1989 124 636 636
Protection against Tuberculosis in Eurasian Wild Boar Vaccinated with Heat-Inactivated Mycobacterium bovis Garrido, Joseba M.; Sevilla, Iker A.; Beltran-Beck, Beatriz; Minguijon, Esmeralda; Ballesteros, Cristina; Galindo, Ruth C.; Boadella, Mariana; Lyashchenko, Konstantin P.; Romero, Beatriz; Victoria Geijo, Maria; Ruiz-Fons, Francisco; Aranaz, Alicia; Juste, Ramon A.; Vicente, Joaquin; de la Fuente, Jose; Gortazar, Christian PLOS ONE 2011 6 e24905 10.1371/journal.pone.0024905
An economic and epidemiologic simulation of different control strategies for ovine paratuberculosis. JUSTE, RA; CASAL, J PREVENTIVE VETERINARY MEDICINE 1993 15 101 115 10.1016/0167-5877(93)90106-4
Latent infections are the most frequent form of paratuberculosis in slaughtered Friesian cattle. Vazquez, P., Garrido, J.M., Molina, E., Geijo, M.V., Gomez, N., Perez, V., Sevilla, I.A., Alonso-Hearn, M., Cortes, A. and Juste, R.A. Spanish Journal of Agricultural Research, 12(4): 1049-1060. DOI: 10.5424/sjar/2014124-5978.
A novel form of human disease with a protease-sensitive prion protein and heterozygosity methionine/valine at codon 129: Case report. Rodriguez-Martinez, Ana B.; Garrido, Joseba M.; Zarranz, Juan J.; Arteagoitia, Jose M.; de Pancorbo, Marian M.; Atares, Begona; Bilbao, Miren J.; Ferrer, Isidro; Juste, Ramon A. BMC NEUROLOGY 2010 10 99 10.1186/1471-2377-10-99. 2014
First case of highly pathogenic H5N1 avian influenza virus in Spain Barral, M.; Alvarez, V.; Juste, R. A.; Agirre, I.; Inchausti, I. BMC VETERINARY RESEARCH 2008 4 50 10.1186/1746-6148-4-50
Atypical/Nor98 scrapie in the Basque Country: a case report of eight outbreaks Rodriguez-Martinez, Ana B.; Garrido, Joseba M.; Maza, Sonia; Benedicto, Leyre; Geijo, Marivi; Gomez, Nieves; Minguijon, Esmeralda; Benestad, Sylvie L.; Juste, Ramon A. BMC VETERINARY RESEARCH 2010 6 17 10.1186/1746-6148-6-17
De La Fuente, Jose; Gortazar, Christian; Juste, Ramon. Complement component 3: a new paradigm in tuberculosis vaccine. EXPERT REVIEW OF VACCINES, 15: 275-277. DOI: 10.1586/14760584.2016.1125294. 2016
Juste RA, Alonso-Hearn M, Garrido JM, Abendano N, Sevilla IA, Gortazar C, de la Fuente J, Dominguez L: Increased Lytic Efficiency of Bovine Macrophages Trained with Killed Mycobacteria. Plos One 2016, 11(11). doi: 10.1371/journal.pone.0165607
Juste RA, Vazquez P, Ruiz-Larrañaga O, Iriondo M, Manzano C, Agirre M, Estonba A, Geijo MV, Molina E, Sevilla IA, Alonso-Hearn M, Gomez N, Perez V, Cortes A, Garrido JM Association between combinations of genetic polymorphisms and epidemiopathogenic forms of bovine paratuberculosis. Heliyon 4 (2018) e00535. doi: 10.1016/j.heliyon.2018.e00535
Balseiro, Ana; Perez, Valentin; Juste, Ramon A. Chronic regional intestinal inflammatory disease: A trans-species slow infection? COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES 2019, 62:88-100. DOI: 10.1016/j.cimid.2018.12.001.

Juste RA, Villoria M, Leginagoikoa I, Ugarte E, Minguijon E. Milk Production losses in Latxa Dairy Sheep associated with small ruminant lentivirus infection, PREVENTIVE VETERINARY MEDICINE. ODI: 10.1016/j.prevetmed.2020.104886

ECSRHM